TUMINI , EMANUELA

Grupos de Investigación

• INESTABILIDAD GENOMICA Y CANCER

Responsable de los siguientes proyectos/ayudas en la US

Participa los siguientes proyectos/ayudas en la US

Proyectos:

• Origen de la Inestabilidad Cromosómica Asociada a Defectos en Transcripción y Replicación ( P12-BIO-1238 - Investigador/a).
• Transcription y Replication como Fuentes de Inestabilidad Genética ( BFU2016-75058-P - Investigador/a).

Publicaciones

Capítulo de Libros:

• Tumini-, Emanuela, Aguilera-Lopez, Andres:
  The Sister-Chromatid Exchange Assay in Human Cells.. Pag. 383 - 393. En: Methods Mol Biol. Springer. 2016. ISBN

Publicaciones en Revistas:

• Tumini-, Emanuela, Herrera-Moyano, Emilia, San Martin-Alonso, Marta, Barroso-Ceballos, Sonia Ines, Galmarini, Cm, Aguilera-Lopez, Andres:
  The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability. En: Molecular Cancer Research. 2019. Vol. 17. Núm. (3). Pag. 773-782 10.1158/1541-7786.MCR-18-0575
• Sertic, Sarah, Mollica, Antonio, Campus, Ilaria, Roma, Stefania, Tumini-, Emanuela, Aguilera-Lopez, Andres, Muzi-falconi, Marco:
  Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions. En: Molecular Cell. 2018. Vol. 70. Núm. 1. Pag. 34-47 10.1016/j.molcel.2018.02.017
• SALAS-ARMENTEROS, IRENE, Perez, Carmen, Bayona, Aleix, Tumini-, Emanuela, Luna-Varo, Rosa Maria, Aguilera, A:
  Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability. En: EMBO Journal. 2017. Vol. 36. Núm. 23. Pag. 3532-3547
• Tumini-, Emanuela, Barroso-Ceballos, Sonia Ines, Perez, Carmen, Aguilera-Lopez, Andres:
  Roles of human POLD1 and POLD3 in genome stability. En: Scientific Reports. 2016. Vol. 6. Núm. . Pag. 38873 -38873
• Garcia-Rubio, Maria Luisa, Perez, Carmen, Barroso-Ceballos, Sonia Ines, Tumini-, Emanuela, Herrera-Moyano, Emilia, Valle-Rosado, Ivan, Aguilera-Lopez, Andres:
  The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.. En: PLoS Genetics. 2015. Vol. 11. Núm. 11. Pag. -e1005674 10.1371/journal.pgen.1005674
• Bhatia-, Vaibhav, Barroso-Ceballos, Sonia Ines, Garcia-Rubio, Maria Luisa, Tumini-, Emanuela, Herrera-Moyano, Emilia, Aguilera-Lopez, Andres:
  BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. En: Nature. 2014. Vol. 511. Núm. 7509. Pag. 362-365
• Rotondo, Guiseppe, Sertic, Sarah, Evolvi, Claudio, Tumini-, Emanuela, Plevani, Paolo, Muzi-falconi, Marco:
  Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.. En: PLoS One. 2013. Vol. 8. Núm. 3. Pag. e60000- 10.1371/journal.pone.0060000
• Tumini-, Emanuela, Plevani, Paolo, Muzi-falconi, Marco, Marini, Federica:
  Physical and functional crosstalk between Fanconi anemia core components and the GINS replication complex. En: DNA Repair. 2011. Vol. 10. Núm. 2. Pag. 149-158
• Ravaglia, Giovanni, Forti, Paola, Maioli, Fabiola, Chiappelli, Martina, Montesi, Fausta, Tumini-, Emanuela, Mariani, Erminia, Licastro, Federico:
  Blood inflammatory markers and risk of dementia: The conselice study of brain aging. En: Neurobiology of Aging. 2007. Vol. 28. Núm. 12. Pag. 1810-1820
• Tumini-, Emanuela, Licastro, Federico, Porcellini, Elisa, Chiappelli, Martina, Conti, Cm, Beraudi, Alina, Poli, Alessandro, Caciagli, F, Doyle, R, Conti, Pio:
  The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimers disease patients. En: Human Psychopharmacology: Clinical and Experimental. 2007. Vol. 22. Núm. 2. Pag. 75-80
• Porcellini, Elisa, Franchesci, Massimo, Licastro, Federico, Calabrese, Elena, Guerini, Franca, Govini, Marzia, Chiapelli, Martina, Tumini-, Emanuela, Morgan, Kevin, Chappell, Sally, Kalsheker, Noor:
  The hydroxy-methyl-glutaryl CoA reductase promoter polymorphism is associated with Alzheimers risk and cognitive deterioration. En: Neuroscience Letters. 2007. Vol. 416. Núm. 1. Pag. 66-70
• Ravaglia, Giovanni, Bolondi, Luigi, Licastro, Federico, Forti, Paola, Maioli, Fabiola, Martelli, Mabel, Montesi, Fausta, Bastagli, Luciana, Bianchin, Marisa, Chiappelli, Martina, Tumini-, Emanuela:
  Interleukin-1 beta and interleukin -6 gene polymorphisms as risk factors for AD: a prospective study. . En: Experimental Gerontology. 2006. Vol. 41. Núm. 1. Pag. 85-92
• Chiappelli, Martina, Tumini-, Emanuela, Porcellini, Elisa, Licastro, Federico:
  Impaired regulation of immune responses in cognitive decline and Alzheimers disease: lessons from genetic association studies. En: Expert Review of Neurotherapeutics. 2006. Vol. 6. Núm. 9. Pag. 1327-1336
• Chiappelli, Martina, Nasi, Milena, Cossarizza, Andrea, Porcellini, Elisa, Tumini-, Emanuela, Pinti, Marcello, Troiano, Leonarda, Franceschi, Massimo, Licastro, Federico:
  Polymorphisms of fas gene: relationship with Alzheimers disease and cognitive decline. En: Dementia and Geriatric Cognitive Disorders. 2006. Vol. 22. Núm. 4. Pag. 296-300
• Chiappelli, Martina, Hoffmann, Enrico, Caruso, Calogero, Licastro, Federico, Tampieri, Cecilia, Tumini-, Emanuela, Porcellini, Elisa, Caldarera, Claudio M, Nanni, Samuele, Branzi, Angelo, Lio, Domenico, Caruso, Marco:
  Interleukin-6 gene polymorphism is an age-dependant risk factor for myocardial infarction in men. En: International Journal of Immunogenetics. 2005. Vol. 32. Núm. 6. Pag. 349-353

Aportaciones a Congresos:

• Tumini-, Emanuela, Herrera-Moyano, Emilia, San Martin-Alonso, Marta, Barroso-Ceballos, Sonia Ines, Galmarini, Carlos M. , Aguilera-Lopez, Andres:
  The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability. Poster en Congreso. Chromosome Architecture and Topological Stress. Baeza (Jaén), España. 2018
• Garcia-Rubio, Maria Luisa, SALAS-ARMENTEROS, IRENE, Perez, Carmen, Herrera-Moyano, Emilia, Tumini-, Emanuela, Barroso-Ceballos, Sonia Ines, Luna-Varo, Rosa Maria, Aguilera-Lopez, Andres:
  RNA-DNA hybrids as a modulator of chromatin structure and genome instability. Ponencia en Congreso. XVI Congress ¿ Sociedad Española de Biología Celular (SEBC). Sevilla, España. 2015
• Garcia-Rubio, Maria Luisa, SALAS-ARMENTEROS, IRENE, García -Pichardo, Desiré, Perez, Carmen, Barroso-Ceballos, Sonia Ines, Tumini-, Emanuela, Luna-Varo, Rosa Maria, Aguilera-Lopez, Andres:
  Role of chromatin and the DNA damage response in R-loop-mediated genome instability. Ponencia en Congreso. EMBO Conference Series on Nuclear Structure and Dynamics. L¿Isle sur la Morgue, Francia. 2015
• Garcia-Rubio, Maria Luisa, SALAS-ARMENTEROS, IRENE, Perez, Carmen, Herrera-Moyano, Emilia, Tumini-, Emanuela, Barroso-Ceballos, Sonia Ines, Luna-Varo, Rosa Maria, Aguilera-Lopez, Andres:
  RNA-DNA hybrids as a modulator of chromatin structure and genome instability in yeast. Ponencia en Congreso. 11th International Meeting on Yeast Apoptosis (IMYA 2015). Oporto. 2015
• Garcia-Rubio, Maria Luisa, SALAS-ARMENTEROS, IRENE, Perez, Carmen, Herrera-Moyano, Emilia, Tumini-, Emanuela, Barroso-Ceballos, Sonia Ines, Luna-Varo, Rosa Maria, Aguilera-Lopez, Andres:
  R-loops as a source of genome instability in yeast and cancer cells. Ponencia en Congreso. 27° International Conference On Yeast Genetics And Molecular Biology, ICYGMB. . 2015
• Tumini-, Emanuela, Barroso-Ceballos, Sonia Ines, Aguilera-Lopez, Andres:
  POLD1 and POLD3 are required for efficient replication origin firing and have differential roles in genome stability. Poster en Congreso. UNIA - Cell division: molecular machineries and cancer targeted therapies. - Baeza (Jaén), España. 2015
• Garcia-Rubio, Maria Luisa, SALAS-ARMENTEROS, IRENE, Perez, Carmen, Herrera-Moyano, Emilia, Tumini-, Emanuela, Barroso-Ceballos, Sonia Ines, Luna-Varo, Rosa Maria, Aguilera-Lopez, Andres:
  RNA-DNA hybrids as a modulator of chromatin structure and genome instability. Ponencia en Congreso. 40TH FEBS CONGRESS. The Biochemical Basis of Life. Berlín, Alemania. 2015
• Garcia-Rubio, Maria Luisa, SALAS-ARMENTEROS, IRENE, Perez, Carmen, Herrera-Moyano, Emilia, Tumini-, Emanuela, Barroso-Ceballos, Sonia Ines, Luna-Varo, Rosa Maria, Aguilera-Lopez, Andres:
  RNA-DNA hybrids as a modulator of chromatin structure and genome instability. Ponencia en Congreso. XL Congreso de la Sociedad Española de Genetica (SEG). Cordoba, España. 2015
• Garcia-Rubio, Maria Luisa, Tumini-, Emanuela, Perez, Carmen, SALAS-ARMENTEROS, IRENE, Luna-Varo, Rosa Maria, Aguilera-Lopez, Andres:
  A role for R-Loops in chromatin reorganization and replication stress as a source of genome instability. Ponencia en Congreso. FASEB Science Research Conferences on genetic recombination & genome rearrangements. Steamboat Springs, CO, USA. 2015
• Tumini-, Emanuela, Aguilera-Lopez, Andres:
  Role of Human POLD3 in Genome Integrity. Comunicación en congreso. 14th ASEICA Internacional Congress. . 2013