MARTÍNEZ FÁBREGAS, JÓNATHAN

Perfil en ORCID: 0000-0001-5809-065X

Perfil en ResearcherID: A-5819-2019

Grupos de Investigación

• Grupo de Metabolismo y Señalización Celular

Responsable de los siguientes proyectos/ayudas en la US

Participa los siguientes proyectos/ayudas en la US

Proyectos:

• BASES ESTRUCTURALES, RECONOCIMIENTO MOLECULAR Y ANÁLISIS EVOLUTIVO DEL CITOCROMO C, UNA PROTEÍNA BIFUNCIONAL MODIFICADA POST- TRADICCIONALMENTE ( BFU2009-07190 - Investigador/a).
• Time-resolved, quantitative characterization of the DNA-damaged induced nuclear cytochrome c by in nuclei-EPR ( MOSBRI-2022-83 - Investigador/a).

Ayudas:

• Consolidación de Grupos de Investigación ( 2011/BIO-198 - Investigador/a ).
• Consolidación a Grupos de Investigación ( 2010/BIO-198 - Investigador/a ).
• Consolidación de Grupos de Investigación ( 2009/BIO-198 - Investigador/a ).
• Consolidación de Grupos de Investigación ( 2008/BIO-198 - Investigador/a ).

Publicaciones

Capítulo de Libros:

• Gonzalez-Arzola, Katiuska, MORENO-BELTRÁN, JOSÉ BLAS, Martínez-Fábregas, Jónathan, De La Rosa-Acosta, Miguel Angel, Díaz-Moreno, Irene:
  Cytochrome c Signalosome. Pag. - . En: Redox proteins in supercomplexes and signalosomes . Crc Press. 2015. ISBN 978-1-4822-5110-4

Publicaciones en Revistas:

• Gonzalez-Arzola, Katiuska, Velazquez-campoy, Adrian, Szulc, Elzbieta, Gavilán-Dorronzoro, María De La Paz, Ayala, Isabel, Arranz, Rocio, Rios-Sanchez, Rosa Maria, Salvatella, Xavier, Valpuesta, Jose M, Hermoso, Jose A, De La Rosa-Acosta, Miguel Angel, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, Bernardo-garcia, Noelia, Martínez-Fábregas, Jónathan, Rivero-Rodríguez, Francisco, Casado, Miguel Ángel, Elena-Real, Carlos Alberto, Velázquez, Alejandro, Gil-caballero, Sergio:
  Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase sep. En: Nature Structural and Molecular Biology. 2022. Vol. . Núm. . Pag. - 10.1038/s41594-022-00842-3
• Martínez-Fábregas, Jónathan, Díaz-Moreno, Irene, Tamargo-azpilicueta, Joaquín:
  Lysosomes: Multifunctional compartments ruled by a complex regulatory network. En: FEBS OPEN Bio. 2022. Vol. 12. Núm. 4. Pag. 758-774 10.1002/2211-5463.13387
• Wilmes, Stephan, Taylor, Charles, Guerrier, Thomas, Launay, David, Mitra, Suman, Piehler, Jacob, Molina-paris, Carmen, Moraga, Ignacio, Jeffrey, Polly-anne, Martínez-Fábregas, Jónathan, Hafer, Maximilian, Fyfe, Paul K, Pohler, Elizabeth, Gaggero, Silvia, Lopez-garcia, Martin, Lythe, Grant:
  Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses. En: eLife. 2021. Vol. 10. Núm. e66014. Pag. 1-44 10.7554/eLife.66014
• Martínez-Fábregas, Jónathan, Pohler, Elizabeth, Moraga, Ignacio:
  Identifying cytokine signatures in primary human Th-1 cells by phospho-proteomics analysis. En: STAR Protocols. 2021. Vol. 2. Núm. 100417. Pag. 1-13 10.1016/j.xpro.2021.100417
• Martínez-Fábregas, Jónathan, Wang, Luopin, Pohler, Elizabeth, Cozzani, Adeline, Wilmes, Stephan, Kazemian, Majid, Mitra, Suman, Moraga, Ignacio:
  CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci. En: Cell Reports. 2020. Vol. 33. Núm. 108545. Pag. 1-16 10.1016/j.celrep.2020.108545
• Martínez-Fábregas, Jónathan, Piehler, Jacob, Kazemian, Majid, Mitra, Suman, Moraga, Ignacio, Wilmes, Stephan, Wang, Luopin, Hafer, Maximilian, Pohler, Elizabeth, Lokau, Juliane, Garbers, Christoph, Cozzani, Adeline, Fyfe, Paul K:
  Kinetics of cytokine receptor trafficking determine signaling and functional selectivity. En: eLife. 2019. Vol. 8. Núm. e49314. Pag. 1-32 10.7554/eLife.49314
• Gorby, Claire, Martínez-Fábregas, Jónathan, Wilmes, Stephan, Moraga, Ignacio:
  Mapping determinants of cytokine signaling via protein engineering. En: Frontiers in Immunology. 2018. Vol. 9. Núm. 2143. Pag. 1-9 10.3389/fimmu.2018.02143
• Martínez-Fábregas, Jónathan, Prescott, Alan, Van Kasteren, Sander, Leslie Pedrioli, Deena, Mclean, Irwin, Moles, Anna, Reinheckel, Thomas, Poli, Valeria, Watts, Colin:
  Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis. En: Nature Communications. 2018. Vol. 9. Núm. 5343. Pag. 1-16 10.1038/s41467-018-007741-6
• Staathopoulo, Chaido, Felizardo, Tania C, Eckhaus, Michael A, Edgington-mitchell, Laura, Martínez-Fábregas, Jónathan, Zhu, Jinfang, Fowler, Daniel H, Van Kasteren, Sander, Laurence, Arian, Bogyo, Matther, Watts, Colin, Gangaplara, Arunakuman, Shevach, Ethan M, Amarnath, Shoba, Mallet, Grace, Flomerfelt, Francis A, Liniany, Lukasz P, Knight, David, Samsel, Leigh A, Berlinguer-palmini, Rolando, Yim, Joshua J:
  PD-1 inhibitory receptor down regulates asparagine endopeptidase and maintains Foxp3 transcription factor stability in induced regulatory T cells. En: Immunity. 2018. Vol. 49. Núm. . Pag. 247-263 10.1016/j.immuni.2018.05.006
• Mallet, Grace, Martínez-Fábregas, Jónathan, Yim, Joshua, Zhu, Jinfang, Fowler, Daniel H, Gangaplara, Arun, Stathopoulo, Chaido, Flomerfelt, Francis, Samsel, Leigh, Felizardo, Tania, Eckhaus, Michael, Edgington, Laura, Edgington, Laura:
  PD-1 through Asparaginyl Endopeptidase Regulates Foxp3 Stability in Induced Regulatory T Cells. En: Blood. 2017. Vol. 130. Núm. . Pag. 4438- 10.1182/blood.V130.Suppl_1.4438.4438
• Mallet, Grace, Martínez-Fábregas, Jónathan, Zhu, Jinfang, Fowler, Daniel H, Bogyo, Matthew, Van Kasteren, Sander, Watts, Colin, Shevach, Ethan, Laurence, Arian, Amarnath, Shoba, Gangaplara, Arun, Stathopoulo, Chaido, Flomerfelt, Francis, Samsel, Leigh, Felizardo, Tania, Eckhaus, Michael, Edgington, Laura, Yim, Joshua:
  PD-1 through Asparaginyl Endopeptidase Regulates Foxp3 Stability in Induced Regulatory T Cells. En: Blood. 2017. Vol. 130. Núm. . Pag. 4438- 10.1182/blood.V130.Suppl_1.4438.4438
• Martínez-Fábregas, Jónathan, De La Rosa-Acosta, Miguel Angel, Díaz-Moreno, Irene, Gonzalez-Arzola, Katiuska, Janocha, Simon, Navarro-Carruesco, José Antonio, Hervás-Morón, Manuel, Bernhardt, Rita, Velázquez-campoy, Adrián, Díaz-Quintana, Antonio:
  Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis . En: Molecular and Cellular Proteomics. 2014. Vol. 13. Núm. . Pag. 1439-1456 10.1074/mcp.M113.034322
• Martínez-Fábregas, Jónathan, Díaz-Moreno, Irene, Gonzalez-Arzola, Katiuska, Díaz-Quintana, Antonio, De La Rosa-Acosta, Miguel Angel:
  A common signalosome for programmed cell death in humans and plants. En: Cell Death & Disease. 2014. Vol. e1314. Núm. 5. Pag. 1-2 doi:10.1038/cddis.2014.280
• Martínez-Fábregas, Jónathan, Díaz-Moreno, Irene, Gonzalez-Arzola, Katiuska, Janocha, Simon, Navarro-Carruesco, José Antonio, Hervás-Morón, Manuel, Bernhardt, Rita , Díaz-Quintana, Antonio, De La Rosa-Acosta, Miguel Angel:
  New Arabidopsis thaliana cytochrome c partners: A look into the elusive role of cytochrome c in programmed cell death in plants. En: Molecular and Cellular Proteomics. 2013. Vol. 12. Núm. . Pag. 3666-3676 10.1074/mcp.M113.030692
• Martínez-Fábregas, Jónathan, Rubio-Novella, Silvia, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, De La Rosa-Acosta, Miguel Angel:
  Proteomic tools for the analysis of transient interactions between metalloproteins. En: The FEBS Journal. 2011. Vol. 278. Núm. 9. Pag. 1401-1410 10.1111/j.1742-4658.2011.08061.x

Aportaciones a Congresos:

• Díaz-Moreno, Irene, Fernández-veloso, Andrea, Rodríguez-rejano, Lucía, GUERRA-CASTELLANO, ALEJANDRA, Corrales-Guerrero, Laura, Martínez-Fábregas, Jónathan, De La Rosa-Acosta, Miguel Angel, Giner, Rafael Luis, Pérez Mejías, Gonzalo, Velázquez, Alejandro, Baños, Blanca, Casado, Miguel Ángel, Rivero-Rodríguez, Francisco, Márquez, Inmaculada, Tamargo-azpilicueta, Joaquín:
  Emerging Functions of Mitochondrial Cytochrome c in the Cytoplasm and Nucleus . Sesión plenaria en Congreso. IUBMB Focused Meeting / FEBS Workshop Crosstalk between Nucleus and Mitochondria in Human Disease. Sevilla, Spain. 2022
• Díaz-Moreno, Irene, Martínez-Fábregas, Jónathan, De La Rosa-Acosta, Miguel Angel, Giner, Rafael Luis, Pérez Mejías, Gonzalo, Velázquez, Alejandro, Baños, Blanca, Casado, Miguel Ángel, Rivero-Rodríguez, Francisco, GUERRA-CASTELLANO, ALEJANDRA, Corrales-Guerrero, Laura:
  Respiratory Cytochrome c: a Master Pleiotropic Cell Regulator. Sesión plenaria en Congreso. European BioEnergetics Conference. Aix en Provence. 2022
• Tamargo-azpilicueta, Joaquín, Martínez-Fábregas, Jónathan, De La Rosa-Acosta, Miguel Angel, Díaz-Moreno, Irene:
  Tyr48 phosphorylation of cytochrome c regulates its binding to nuclear histone chaperones. Poster en Congreso. FEBS-IUBMB-ENABLE 1st International Molecular Biosciences PhD and Postdoc Conference. Sevilla, España. 2022
• Tamargo-azpilicueta, Joaquín, Martínez-Fábregas, Jónathan, De La Rosa-Acosta, Miguel Angel, Díaz-Moreno, Irene:
  Biophysical insights into the role of cytochrome c phosphorylation in its interaction with histone chaperones. Poster en Congreso. XVIII Simposio de Jóvenes Investigadores Químicos. Sevilla. 2022
• Gonzalez-Arzola, Katiuska, MORENO-BELTRÁN, JOSÉ BLAS, Martínez-Fábregas, Jónathan, Elena-Real, Carlos Alberto, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, De La Rosa-Acosta, Miguel Angel:
  A Common Role for Cytochrome c in Programmed Cell Death in Humans and Plants. Poster en Congreso. The 29th Annual Symposium of The Protein Society. Barcelona España. 2015
• Gonzalez-Arzola, Katiuska, Martínez-Fábregas, Jónathan, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, De La Rosa-Acosta, Miguel Angel:
  A Common Signalosome for Programmed Cell Death in Humans and Plants. Comunicación en congreso. Young Scientists Program (YSP) IUBMB-SBBq. Sao Paulo, Brasil. 2015
• Gonzalez-Arzola, Katiuska, Martínez-Fábregas, Jónathan, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, De La Rosa-Acosta, Miguel Angel:
  Programmed Cell Death Uses Similar Pathways in Plants and Humans. Poster en Congreso. 23rd IUBMB and 44th SBBq Congress . Foz do Iguaçu (Brasil). 2015
• Gonzalez-Arzola, Katiuska, Martínez-Fábregas, Jónathan, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, De La Rosa-Acosta, Miguel Angel:
  A Common Cytochrome c-centred Signalosome for Programmed Cell Death in Humans and Plants. Sesión no plenaria en Congreso. 23rd IUBMB and 44th Annual Meeting of the SBBq. FOZ DO IGAZU, PARANÁ, BRASIL. 2015
• Díaz-Moreno, Irene, Martínez-Fábregas, Jónathan, Gonzalez-Arzola, Katiuska, Díaz-Quintana, Antonio, De La Rosa-Acosta, Miguel Angel:
  A common link for programmed cell death in humans and plants. Ponencia en Congreso. 18th European Bioenergetics Conference (EBEC). Lisboa, Portugal. 2014
• Gonzalez-Arzola, Katiuska, Martínez-Fábregas, Jónathan, Díaz-Quintana, Antonio, Janocha, Simon, Bernhardt, Rita, Velázquez -campoy, Adrian , Díaz-Moreno, Irene, De La Rosa-Acosta, Miguel Angel:
  A common signalosome for programmed cell death in humans and plants. Sesión no plenaria en Congreso. XXXVII Congreso Sociedad Española de Bioquímica y Biología Molecular. Granada. 2014
• Gonzalez-Arzola, Katiuska, Martínez-Fábregas, Jónathan, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, De La Rosa-Acosta, Miguel Angel:
  New Role of Cytochrome c in Programmed Cell Death. Poster en Congreso. FEBS EMBO 2014 Conference. Paris, France. 2014
• Díaz-Moreno, Irene, Martínez-Fábregas, Jónathan, Gonzalez-Arzola, Katiuska, Díaz-Quintana, Antonio, De La Rosa-Acosta, Miguel Angel:
  A Commom Link for Programmed Cell Death in Humans and Plants. Sesión no plenaria en Congreso. XIV Congress of the Spanish Biophysical Society (SBE). . 2014
• Gonzalez-Arzola, Katiuska, Martínez-Fábregas, Jónathan, MORENO-BELTRÁN, JOSÉ BLAS, Elena-real, Carlos, Díaz-Moreno, Irene, Díaz-Quintana, Antonio, De La Rosa-Acosta, Miguel Angel:
  Nuevas proteínas diana del citocromo c en apoptosis. Poster en Congreso. XXXVI CONGRESO DE LA SOCIEDAD ESPAÑOLA DE BIOQUÍMCA Y BIOLOGÍA MOLECULAR (SEBBM). . 2013
• Díaz-Moreno, Irene, Díaz-Quintana, Antonio, De La Rosa-Acosta, Miguel Angel, Martínez-Fábregas, Jónathan, Gonzalez-Arzola, Katiuska, Cruz-Gallardo, Isabel, MORENO-BELTRÁN, JOSÉ BLAS, GUERRA-CASTELLANO, ALEJANDRA, Elena-Real, Carlos Alberto, Garcia-Heredia, Jose Manuel, Rivero-Rodríguez, Francisco:
  Biointeractomic scaffold hovering on cytochrome c under programmed cell death. Sesión plenaria en Congreso. XII PABMB CONGRESS XXXVI ANNUAL MEETING SOCIEDAD DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR DE CHILE XLIX ANNUAL MEETING SOCIEDAD ARGENTINA DE INVESTIGACIÓN B. PUERTO VARAS, CHILE. 2013
• Díaz-Moreno, Irene, Martínez-Fábregas, Jónathan, Gonzalez-Arzola, Katiuska, Díaz-Quintana, Antonio, De La Rosa-Acosta, Miguel Angel:
  Biointeractomics of cytochrome c under programmed cell death in plants and humans. Ponencia en Congreso. 38th FEBS Congress. SAINT PETERSBURG, RUSIA. 2013
• Martínez-Fábregas, Jónathan, Díaz-Moreno, Irene, Díaz-Quintana, Antonio, De La Rosa-Acosta, Miguel Angel:
  Cytochrome c: an old protein controlling life and death since the dawn of time. Poster en Congreso. 22nd IUBMB & 37th FEBS Congress. Palacio de Congresos Sevilla. 2012
• Martínez-Fábregas, Jónathan, Díaz-Moreno, Irene, Rubio-Novella, Silvia, Díaz-Quintana, Antonio, Hervás-Morón, Manuel, Navarro-Carruesco, José Antonio, De La Rosa-Acosta, Miguel Angel:
  BIOINTERACTOMIC SCAFFOLD HOVERING OVER APOPTOTIC CYTOCHROME C.. Poster en Congreso. XXXIV CONGRESO SEBBM (34) (34.2011.BARCELONA). . 2011
• Martínez-Fábregas, Jónathan, Rubio-Novella, Silvia, Navarro-Carruesco, José Antonio, Hervás-Morón, Manuel, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, De La Rosa-Acosta, Miguel Angel:
  IDENTIFICACIÓN DE NUEVAS DIANAS DEL CITOCROMO C EN ARABIDOPSIS THALIANA Y HOMO SAPIENS.. Poster en Congreso. XXXIII CONGRESO DE LA SOCIEDAD ESPAÑOLA DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR . CÓRDOBA, ESPAÑA. 2010
• Rubio-Novella, Silvia, Martínez-Fábregas, Jónathan, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, De La Rosa-Acosta, Miguel Angel:
  HIGH-THROUGHPUT SCREENING OF CYTOCHROME C NOVEL PARTNERS IN CHLAMYDOMONAS REINHARDTII. Comunicación en congreso. XXXIII CONGRESO DE LA SOCIEDAD ESPAÑOLA DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR . CÓRDOBA, ESPAÑA. 2010
• De La Rosa-Acosta, Miguel Angel, Garcia-Heredia, Jose Manuel, Navarro-Carruesco, José Antonio, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, Martínez-Fábregas, Jónathan, Nieto-Mesa, Pedro Manuel, Rubio-Novella, Silvia, Orzáez-,Mar, Kocanis-, Stella, Teixeira-,Miguel, Pérez-Payá-,Enrique, Hervás-Morón, Manuel:
  STRUCTURAL AND FUNCTIONAL CHANGES INDUCED BY TYROSINE NITRATION IN CYTOCHROME C, A BI-FUNCTIONAL PROTEIN. Conferencia Congreso no publicada. 16TH EUROPEAN BIOENERGETICS CONFERENCE () (.2010.VARSOVIA). VARSOVIA. 2010
• Martínez-Fábregas, Jónathan, Navarro-Carruesco, José Antonio, Hervás-Morón, Manuel, Díaz-Quintana, Antonio, Díaz-Moreno, Irene, De La Rosa-Acosta, Miguel Angel:
  SCREENING OF NOVEL PROTEINS INTERACTING WITH ALGAL, PLANT AND HUMAN CYTOCHROME C. Comunicación en congreso. WORKSHOP ON UNDERSTANDING TRANSIENT MOLECULAR INTERACTIONS IN BIOLOGY. () (.2010.SEVILLA, ESPAÑA). Santander (ESPAÑA). 2010