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SARMIENTO SOTO, MANUELPerfil en ORCID: 0000-0003-0997-0153 Perfil en ResearcherID: L-7417-2016 Grupos de Investigación - MECANISMOS DE MUERTE CELULAR EN ENFERMEDADES NEURODEGENERATIVAS
Responsable de los siguientes proyectos/ayudas en la USParticipa los siguientes proyectos/ayudas en la USProyectos: - Estudio ESTUDIO DE LOS CAMBIOS QUE EXPERIMENTAN CON EL ENVEJECIMIENTO LAS RUTAS QUE PROMUEVEN LA SUPERVIVENCIA CELULAR Y LA INFLAMACION CEREBRAL: MODU ( P09-CTS-5244; 2010 - Investigador/a).
- ESTUDIO DE LA POSIBLE INFLUENCIA DE LOS PROCESOS INFLAMATORIOS PERIFÉRICOS SOBRE LA DEGENERACIÓN DEL SISTEMA DOPAMINÉRGICO NEGRO- ESTRIATAL ( SAF2008-04366 - Investigador/a).
Ayudas: - Incentivo al Grupo de Investigación BIO-158 ( 2010/BIO-158 - Investigador/a ).
- Ayuda a la Consolidación del Grupo de Investigación BIO-158 ( 2009/BIO-158 - Investigador/a ).
PublicacionesCapítulo de Libros: - Sarmiento-Soto, Manuel:
Mouse Models of Brain Metastasis for Unravelling Tumour Progression. Pag. 231 - 244. En: Tumor Microenvironment. Springer Nature. 2016. ISBN
Publicaciones en Revistas: - Folgado-dorado, Carlos, Sarmiento-Soto, Manuel, Carracena-de La Corte, Julia, Aguilera, Jose Raúl, Santana, Rafabel, Rivera Ramos, Alberto, Carbonero-Aguilar, Maria Del Pilar, Talaverón-Aguilocho, Rocío, Bautista-Palomas, Juan Dionisio:
Isolation and Purification of Fungal ß-Glucan as an Immunotherapy Strategy for Glioblastoma. En: Journal of Visualized Experiments. 2023. Vol. e64924. Núm. . Pag. 1-17 10.3791/64924 - Hajji-, Nabil, Mateos-Cordero, Santiago, Shah, Khalid, Bomalaski, John, Anichini, Giulio, Tzakos, Andreas G, Crook, Timothy, O¿neill, Kevin, Scheck, Adrienne C, Venero-Recio, Jose Luis, Syed, Nelofer, García-revilla, Juan, Sarmiento-Soto, Manuel, Perryman, Richard, Symington, Jake, Quarles, Chad C, Healey, Deborah R, Guo, Yijie, Orta-Vázquez, Manuel Luis:
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors. En: Journal of Clinical Investigation. 2022. Vol. 132. Núm. . Pag. e142137- https://www.jci.org/articles/view/142137 - Sarmiento-Soto, Manuel:
The Role of the Immune Response in Brain Metastasis. En: Frontiers in Oncology. 2022. Vol. . Núm. . Pag. - - Sarmiento-Soto, Manuel:
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration. En: Cell Death & Disease. 2022. Vol. . Núm. . Pag. - - Sarmiento-Soto, Manuel:
A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis mode. En: Journal of Cerebral Blood Flow and Metabolism. 2021. Vol. . Núm. . Pag. - - Sarmiento-Soto, Manuel:
STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction. En: Cancer Research. 2021. Vol. . Núm. . Pag. - - Sarmiento-Soto, Manuel:
VCAM-1 targeted alpha-particle therapy for early brain metastases. En: Neuro-Oncology. 2020. Vol. . Núm. . Pag. - - García-revilla, Juan, Santiago-Pavon, Martiniano, Rodriguez-Gómez, Jose Antonio, Sarmiento-Soto, Manuel, Martinez-De Pablos, Rocio, Venero-Recio, Jose Luis, Alonso, Isabel Maria, Burguillos-García, Miguel Angel, Herrera-Carmona, Antonio Jose, Ruiz-Laza, Rocío, Espinosa-Oliva, Ana Maria, Cruz, Luis, García-domínguez, Irene, Roca, Mª Angustias:
Reformulating pro-oxidant microglia in neurodegeneration. En: Journal of Clinical Medicine. 2019. Vol. 8. Núm. 10. Pag. 1719- 10.1016/j.celrep.2019.09.013 - Sarmiento-Soto, Manuel:
Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy. En: Molecular Cancer Therapeutics. 2019. Vol. . Núm. . Pag. - - Sarmiento-Soto, Manuel:
VCAM-1 targeted magnetic resonance imaging enables detection of brain micrometastases from different primary tumours. En: Clinical Cancer Research. 2018. Vol. . Núm. . Pag. - 10.1158/1078-0432.CCR-18-1889 - Sarmiento-Soto, Manuel:
Optimization of molecularly targeted MRI in brain: empirical comparison of sequences and particles. En: International Journal of Nanomedicine. 2018. Vol. . Núm. . Pag. - 10.2147/IJN.S158071 - Sarmiento-Soto, Manuel:
Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases. En: Theranostics. 2018. Vol. . Núm. . Pag. - - Sarmiento-Soto, Manuel:
The Multifarious Role of Microglia in Brain Metastasis. En: Frontiers In Cellular Neuroscience. 2018. Vol. . Núm. . Pag. - 10.3389/fncel.2018.00414 - Sarmiento-Soto, Manuel:
Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI. En: Nature Communications. 2017. Vol. . Núm. . Pag. - - Sarmiento-Soto, Manuel:
Anti-inflammatory Microglia/Macrophages As a Potential Therapeutic Target in Brain Metastasis. En: Frontiers in Oncology. 2017. Vol. . Núm. . Pag. - - Sarmiento-Soto, Manuel:
Disruption of tumour-host communication by downregulation of LFA-1 reduces COX-2 and e-NOS expression and inhibits brain metastasis growth. En: Oncotarget. 2016. Vol. . Núm. . Pag. - - Sarmiento-Soto, Manuel:
Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion. En: Current Biology. 2015. Vol. . Núm. . Pag. - - Delgado-Cortes, Maria Jose, Martinez-De Pablos, Rocio, Espinosa-Oliva, Ana Maria, Sarmiento-Soto, Manuel, Argúelles-Castilla, Sandro, Herrera-Carmona, Antonio Jose, Mauriño-Campanario, Raquel María, Fernandez-Villaran, Ruth, Venero-Recio, Jose Luis, Machado-De La Quintana, Alberto:
Synergistic deleterious effect of chronic stress and sodium azide in the mouse hippocampus.. En: Chemical Research in Toxicology. 2015. Vol. 28. Núm. 4. Pag. 651-661 10.1021/tx5004408 - Sarmiento-Soto, Manuel:
Structural and functional effects of metastases in rat brain determined by multimodal MRI. En: International Journal of Cancer. 2014. Vol. . Núm. . Pag. - - Espinosa-Oliva, Ana Maria, Martinez-De Pablos, Rocio, Sarmiento-Soto, Manuel, Fernandez-Villaran, Ruth, Carrillo-Jimenez, Alejandro, Santiago-Pavon, Martiniano, Venero-Recio, Jose Luis, Herrera-Carmona, Antonio Jose, Machado-De La Quintana, Alberto:
Role of dopamine in the recruitment of inmune cells to the nigrostriatal dopaminergic structures. En: Neurotoxicology. 2014. Vol. 41. Núm. C. Pag. 89-101 10.1016/j.neuro.2014.01.006 - Sarmiento-Soto, Manuel:
ASPP2 controls epithelial plasticity and inhibits metastasis through ß-catenin-dependent regulation of ZEB1. En: Nature Cell Biology. 2014. Vol. . Núm. . Pag. - - Martinez-De Pablos, Rocio, Herrera-Carmona, Antonio Jose, Espinosa-Oliva, Ana Maria, Sarmiento-Soto, Manuel, Muñoz-Pinto, Mario Faustino, Machado-De La Quintana, Alberto, Venero-Recio, Jose Luis:
Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation. En: Journal of Neuroinflammation. 2014. Vol. 11. Núm. 1. Pag. 34-44 10.1186/1742-2094-11-34 - Machado-De La Quintana, Alberto, Delgado-Cortes, Maria Jose, Argúelles-Castilla, Sandro, Cano-Garcia, Josefina, Herrera-Carmona, Antonio Jose, Martinez-De Pablos, Rocio, Espinosa-Oliva, Ana Maria, Sarmiento-Soto, Manuel, Ayala-Gomez, Antonio, Venero-Recio, Jose Luis, Santiago-Pavon, Martiniano, Fernandez-Villaran, Ruth:
Chronic stress as a risk factor for Alzheimer's disease. En: Reviews in the Neurosciences. 2014. Vol. 25. Núm. 6. Pag. 785-804 10.1515/revneuro-2014-0035 - Martinez-De Pablos, Rocio, Sarmiento-Soto, Manuel, Espinosa-Oliva, Ana Maria:
Creating a rat model of chronic variate stress. En: Bio-Protocol. 2014. Vol. 4. Núm. 23. Pag. 1-7 10.21769/BioProtoc.1315 - Sarmiento-Soto, Manuel:
Functional role of endothelial adhesion molecules in the early stages of brain metastasis. En: Neuro-Oncology. 2014. Vol. . Núm. . Pag. - - Martinez-De Pablos, Rocio, Espinosa-Oliva, Ana Maria, Sarmiento-Soto, Manuel, Venero-Recio, Jose Luis:
Stress and inflammation: a detrimental combination in the development of neurodegenerative disease. En: Inflammation and Cell Signaling. 2014. Vol. 1. Núm. . Pag. e182- - Sarmiento-Soto, Manuel:
Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker. En: The Journal of Nuclear Medicine. 2014. Vol. . Núm. . Pag. - - Martinez-De Pablos, Rocio, Sarmiento-Soto, Manuel:
Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis.. En: Journal of Cerebral Blood Flow and Metabolism. 2013. Vol. 33. Núm. 5. Pag. 744-753 10.1038/jcbfm.2013.12. - Sarmiento-Soto, Manuel:
Molecular MRI enables early and sensitive detection of brain metastases. En: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2012. Vol. . Núm. . Pag. - - Machado-De La Quintana, Alberto, Delgado-Cortes, Maria Jose, Mauriño-Campanario, Raquel María, Cano-Garcia, Josefina, Herrera-Carmona, Antonio Jose, Venero-Recio, Jose Luis, Santiago-Pavon, Martiniano, Martinez-De Pablos, Rocio, Fernandez-Villaran, Ruth, Espinosa-Oliva, Ana Maria, Argúelles-Castilla, Sandro, Sarmiento-Soto, Manuel:
Inflammatory animal models for parkinson's disease: the intranigral injection of LPS induced the inflammatory process along with the selective degener. En: ISRN Neurology. 2011. Vol. 2011. Núm. . Pag. 1-16 10.5402/2011/476158 - Machado-De La Quintana, Alberto, Delgado-Cortes, Maria Jose, Mauriño-Campanario, Raquel María, Cano-Garcia, Josefina, Herrera-Carmona, Antonio Jose, Venero-Recio, Jose Luis, Santiago-Pavon, Martiniano, Martinez-De Pablos, Rocio, Fernandez-Villaran, Ruth, Espinosa-Oliva, Ana Maria, Argúelles-Castilla, Sandro, Sarmiento-Soto, Manuel:
Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in Prkinson's dise. En: Parkinson's Disease. 2011. Vol. 2011. Núm. . Pag. 1-9 10.4061/2011/393769 - Espinosa-Oliva, Ana Maria, Martinez-De Pablos, Rocio, Fernandez-Villaran, Ruth, Sarmiento-Soto, Manuel, Herrera-Carmona, Antonio Jose, Machado-De La Quintana, Alberto:
PROAGING EFFECTS OF STRESS: A REVIEW. En: Medicina Antienvejecimiento. 2010. Vol. 14. Núm. . Pag. 33-54 - Martinez-De Pablos, Rocio, Villaran-Fernandez,Ruth, Espinosa-Oliva, Ana Maria, Cano-,Josefina, Machado-De La Quintana, Alberto, Sarmiento-Soto, Manuel, De Pablos-,Rocio, Argüelles-,Sandro, Delgado-Cortes, Maria Jose, Sobrino-Cabello, Verónica, Van Rooijen-,Nico, Venero-Recio, Jose Luis, Herrera-,A.J.:
ULCERATIVE COLITIS EXACERBATES LIPOPOLYSACCHARIDE-INDUCED DAMAGE TO THE NIGRAL DOPAMINERGIC SYSTEM: POTENTIAL RISK FACTOR IN PARKINSON`S DISEASE. En: Journal of Neurochemistry. 2010. Vol. 114. Núm. 6. Pag. 1687-1700 - Pasaro-Dionisio, M. Rosario, Ribas-Salgueiro, Juan Luis, Rodriguez-Matarredona, Esperanza, Sarmiento-Soto, Manuel, Ribas-Serna, Juan:
SYSTEMIC INHIBITION OF THE NA(+)/H (+) EXCHANGER TYPE 3 IN INTACT RATS ACTIVATES BRAINSTEM RESPIRATORY REGIONS.. En: Advances in Experimental Medicine and Biology. 2009. Vol. 648. Núm. . Pag. 395-401 - Ribas-Salgueiro, Juan Luis, Rodriguez Matarredona, Esperanza, Sarmiento-Soto, Manuel, Ribas-Serna, Juan, Pasaro-Dionisio, M. Rosario:
RESPIRATORY RESPONSE TO SYSTEMIC INHIBITION OF THE NA+/H+ EXCHANGER TYPE 3 IN INTACT RATS. En: Respiratory Physiology & Neurobiology. 2009. Vol. 165. Núm. . Pag. 254-260 10.1016/j.resp.2008.12.011 - Ribas-Serna, Juan, Sarmiento-Soto, Manuel, Rodriguez Matarredona, Esperanza, Ribas-Salgueiro, Juan Luis, Pasaro-Dionisio, M. Rosario:
INHIBITION OF NA+/H+ EXCHANGER TYPE 3 INCREASES BREATHING FREQUENCY AND ACTIVATES CENTRAL CARDIORESPIRATORY NEURONS IN RATS. En: Acta Physiologica. 2007. Vol. 190. Núm. SUPP 655. Pag. 54-55 - Sarmiento-Soto, Manuel, Rodriguez-Matarredona, Esperanza, Ribas-Salgueiro, Juan Luis, Ribas-Serna, Juan, Pasaro-Dionisio, M. Rosario:
SELECTIVE INHIBITION OF NA+/H+ EXCHANGER TYPE 3 ACTIVATES BRAINSTEM REGIONS INVOLVED IN CENTRAL CHEMORECEPTION AND HYDROELECTROLYTIC CONTROL. En: Clinical Autonomic Research. 2006. Vol. 16. Núm. 5. Pag. 326-326 - Sarmiento-Soto, Manuel:
CHRONIC STRESS SHOULD BE CONSIDERED A RISK FACTOR FOR ALZHEIMER¿S DISEASE. En: Journal of Neurochemistry. . Vol. . Núm. . Pag. -
Aportaciones a Congresos: - Martinez-De Pablos, Rocio, Economopoulus, Vasiliki , Herrera-Carmona, Antonio Jose, R.-sibson, Nicola, Machado-De La Quintana, Alberto, Venero-Recio, Jose Luis, Espinosa-Oliva, Ana Maria, Boza-serrano, Antonio , Sarmiento-Soto, Manuel, Ruiz-Laza, Rocío, Santiago-Pavon, Martiniano, Oliva-Martín, María José, Roca-ceballos, María Angustias, Serres, Sebastian:
Ulcerative colitis induces the activation of microglia in the ventral mesencephalon along with dopaminergic neuronal death. . Poster en Congreso. XIII European Meeting on Glial Cells in Health and Disease. EDIMBURGO. REINO UNIDO. 2017 - Espinosa-Oliva, Ana Maria, Martinez-De Pablos, Rocio, Delgado-Cortes, Maria Jose, Sarmiento-Soto, Manuel, Argúelles-Castilla, Sandro, Herrera-Carmona, Antonio Jose, Mauriño-Campanario, Raquel María, Fernandez-Villaran, Ruth, Venero-Recio, Jose Luis, Machado-De La Quintana, Alberto:
Chronic stress and sodium azide: a lethal combination for the mouse hippocampus. . Poster en Congreso. 16 National Congress of the Spanish Society of Neuroscience. Granada. 2015 - Oliva-Martín, María José, Boza-serrano, Antonio, Espinosa-Oliva, Ana Maria, Martinez-De Pablos, Rocio, Sarmiento-Soto, Manuel, Santiago-Pavon, Martiniano, Herrera-Carmona, Antonio Jose, Venero-Recio, Jose Luis:
Ulcerative colitis as a potential risk factor for Parkinson's disease. Poster en Congreso. 9th FENS Forum. Milán. 2014 - Espinosa-Oliva, Ana Maria, Martinez-De Pablos, Rocio, Sarmiento-Soto, Manuel, Fernandez-Villaran, Ruth, Herrera-Carmona, Antonio Jose, Cano-Garcia, Josefina, Machado-De La Quintana, Alberto:
Implication of dopamine in the recruitment of immune cells. . Comunicación en congreso. XV Congreso De La Sociedad Española De Neurociencia (SENC) (2013) Oviedo. Oviedo. 2013 - Sarmiento-Soto, Manuel:
Interaction endothelium-cancer cell: Inevitable step towards brain metastases.. Poster en Congreso. keystone Symposia. DUBLIN - IRLANDA. 2012 - Espinosa-Oliva, Ana Maria, Santiago-Pavon, Martiniano, Venero-Recio, Jose Luis, Herrera-Carmona, Antonio Jose, Cano-Garcia, Josefina, Machado-De La Quintana, Alberto, Hernandez-Romero, Maria Del Carmen, Delgado-Cortes, Maria Jose, Sarmiento-Soto, Manuel, Martínez-de Pablos, Rocío, Arguelles, Sandro, Bández, Manuel J, Fernández-villarán, Ruth, Mauriño-Campanario, Raquel María:
PERIPHERAL INFLAMMATION INCREASES THE DELETERIOUS EFFECT OF CNS INFLAMMATION ON THE NIGROSTRIATAL DOPAMINERGIC SYSTEM. Poster en Congreso. 8TH FENS FORUM OF NEUROSCIENCE. . 2012 - Sarmiento-Soto, Manuel, Espinosa-Oliva, Ana Maria, Machado-De La Quintana, Alberto, Delgado-Cortes, Maria Jose, Argúelles-Castilla, Sandro, Martinez-De Pablos, Rocio, Fernandez-Villaran, Ruth, Van-Rooijen,N., Venero-Recio, Jose Luis, Herrera-Carmona, Antonio Jose, Cano-Garcia, Josefina:
PERIPHERAL INFLAMMATION ENHANCES LIPOPOLYSACCHARIDE-INDUCED DAMAGE TO THE NIGROSTRIATAL DOPAMINERGIC SYSTEM: POSSIBLE IMPLICAION IN PARKINSON'S DISEAS. Poster en Congreso. 7 TH FENS FORUM OF EUROPEAN NEUROSCIENCE (7) (7.2010.AMSTERDAM). AMSTERDAM. 2010 - Pasaro-Dionisio, M. Rosario, Ribas-Salgueiro, Juan Luis, Rodriguez Matarredona, Esperanza, Sarmiento-Soto, Manuel, Ribas-Serna, Juan:
RESPIRATORY RESPONSE TO SYSTEMIC INHIBITION OF THE NA+/H+ EXCHANGER TYPE 3 IN INTACT RATS. Comunicación en congreso. MEETING OF THE IINTERNATIONAL SOCIETY FOR ARTERIAL CHEMORECEPTION (17) (17.2008.VALLADOLID). VALLADOLID. 2008 - Sarmiento-Soto, Manuel, Ribas-Salgueiro, Juan Luis, Ribas-Serna, Juan, Rodriguez Matarredona, Esperanza, Pasaro-Dionisio, M. Rosario:
¿SELECTIVE INHIBITION OF NA+/H+ TYPE 3 EXCHANGER ACTIVATES BRAINSTEM REGIONS INVOLVED IN CENTRAL CHEMORECEPTION AND HYDROELECTROLYTIC CONTROL¿.. Comunicación en congreso. 17TH INTERNATIONAL SYMPOSIUM ON THE AUTONOMIC NERVOUS SYSTEM (17) (17.2006.PUERTO RICO). PUERTO RICO. 2006
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